AH, FWI and THM conceived and designed the study. Cerebral cortex consists of three levels; molecular layer, granular layer and a layer of Purkinje. Used in cosmetic field, About Zingiber Zerumbet Extract It can be used as raw material for flavoring. Brocardo PS, Gil-Mohapel J, Christie BR. Mol Asp Med. Zingiber zerumbet is a very forgiving tropical. In addition, an increase in the antioxidant activity can be described as an adaptive response to excessive ROS [42]. Zerumbone is a sesquiterpene phytochemical from a type of edible ginger known as China Zingiber Zerumbet Smith grown in South China or "Zingiber aromaticum". Anal Biochem. AH, FWI and MAL reviewed the manuscript. Zingiber amaricans Blume. volume 18, Article number: 101 (2018) 1987;161(2):559–66. Learn more | Legal Disclaimer. Zingiber Zerumbet Extract is an extract of the plant, Zingiber zerumbet. Both doses of extracts also significantly increased the level of serum superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities as well as glutathione (GSH) level (p < 0.05). By using this website, you agree to our Build Your Own Report For the histological observation of the cerebellum, this study showed that the distance between any two Purkinje cells was larger in ethanol-induced rats, but a detailed and systematic calculation of the distance is required to be carried out to elucidate this issue. 2016; https://doi.org/10.1155/2016/9815092. Arch Biochem Biophys. Manage cookies/Do not sell my data we use in the preference centre. Necropsy examinations of chronic alcoholics have shown a variety of structural and functional alterations in the neurons [10]. Note the number and shape of neuron cells. Harrison-Findik DD, Lu S. The effect of alcohol and hydrogen peroxide on liver hepcidin gene expression in mice lacking antioxidant enzymes, glutathione peroxidase-1 or catalase. Alcohol is a commonly abused substance worldwide that generates reactive oxygen species (ROS) whether it is consumed acutely or chronically [1]. 2013;1(3):48–55. Role of oxidative stress in the protective effects of Zingiber zerumbet Smith ethyl-acetate extract against paracetamol-induced hepatotoxicity in Sprague-Dawley rats. Article  Article  Elevation of MDA level showed that alcohol produced ROS and caused oxidative stress in the brain. PubMed Central  Values are expressed as mean ± SEM. 2005;25(37):8402–6. It was also shown that Z. officinale at the dose of 200 mg/kg body weight could protect the brain against ischemic brain damage and reduced cognitive deficits in a rat model of focal cerebral ischemia induced by the occlusion of the right middle cerebral artery. 3) and normal neuron cells in the cerebral cortex (Fig. This study showed that Z. zerumbet extract administration increased the activities of SOD and CAT in the serum and brain homogenate. That is why both cerebral cortex and cerebellum are the main target in this study. Rains JL, Jain SK. The experiment involving the animals was approved according to animal handling guidelines provided by the UKM Animal Ethics Committee (FSK/BIOMED/2012/ASMAH/21-NOV/475-NOV-2012-JUNE-2013). Privacy Wudpecker J Food Technol. Mol Vis. The rhizomes of Z. zerumbet are used to treat ulcerative colitis [19] to cure dyspepsia wound, hemorrhoids, and stomach discomfort [20]. Zingiber cochinchinense Gagnep. The relationship between plasma triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis. The rhizomes then underwent similar process with ethyl acetate followed by methanol. Assessment report on Zingiber officinale Roscoe, rhizoma . 2012; https://doi.org/10.1155/2012/428010. Trichloroacetic acid (TCA) was used to precipitate the protein. It has cone shaped bracts. PubMed online scientific bibliography data. Neuronal cells are highly dependent on glucose for ATP generation and the production of ROS as a product of oxidative phosphorylation in the mitochondria. Murakami A, Takahashi D, Kinoshita T, Koshimizu K, Kim HW, Yoshihiro A, Nakamura Y, Jiwajinda S, Terao J, Ohigashi H. Zerumbone, a southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the α, β-unsaturated carbonyl group is a prerequisite. The rhizomes of Z. zerumbet, particularly, have been regularly used as food flavouring and appetizer in various Malays' cuisines while the rhizomes extracts have been used in Malay traditional medicine to treat various types of ailments (e.g., inflammatory- and pain … The young stems, rhizomes … Cancer . Wattanathorn J, Phunchago N, Muchimapura S, Thukhum-Mee W, Chaisiwamongkol K, Kaewrueng W, Wongareonwanakij S. Mulberry fruit mitigates alcohol neurotoxicity and memory impairment induced by chronic alcohol intake. One brain region that is particularly sensitive to early ethanol exposure is the cerebellum. Haorah J, Ramirez SH, Floreani N, Gorantla S, Morsey B, Persidsky Y. The role of oxidative stress in fetal alcohol spectrum disorders. Ethyl-acetate extract of Z. zerumbet has protective effects against ethanol-induced brain damage and this is mediated through its antioxidant properties. Thus, it could be speculated that Z. zerumbet extract may induce GSH synthesis by protecting the brain against ethanol-induced damage through similar mechanism. 2011;5(8):1519–25. Zingiber zerumbet (L.) Smith: a review of its Ethnomedicinal, chemical, and pharmacological uses. PubMed Central  CAT enzyme involves in the conversion of H2O2 to H2O and O2. Brain is rich in polyunsaturated fatty acids and iron. Anti-hypersensitive and anti-inflammatory activities of water extract of Zingiber zerumbet (L.) Smith / Hso-Chi Chaung et al / Food and Agricultural Immunology, Volume 19, Issue 2 June 2008 , pages 117 - 129 / DOI: 10.1080/09540100802047783 Zingiber zerumbet (L) Smith well known as lempuyang, is a wild ginger belonging to the Zingiberaceae family, and has been used as an ingredient in some traditional medicines. Learn more | Legal Disclaimer, Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Necrosis was observed in neuron cells (cerebral cortex) of ethanol-induced group with pyknotic characteristic such as darken nucleus and loss of its normal shape under light microscope. 2012;9(4):484–91. Environmental Working Group. PubMed Central  Although it is metabolized mainly in the liver, it also causes toxic effects to the brain [2]. Free Radic Biol Med. The concoction of Zingiber zerumbet rhizomes is normally drunk to treat indigestion, stomachache, fever and worm infestation. The ability of Z. zerumbet to protect brain tissues from lipid peroxidation and protein oxidation is in agreement with Hamid et al. Herbal substance(s) (binomial scientific name of the plant, including plant part) The present study investigates the amelioration of diabetic retinopathy (DR) by Zingiber zerumbet rhizome ethanol extracts (ZZRext) in streptozotocin-induced diabetic rats (STZ-diabetic rats). It is also known to possess antioxidant and anti-inflammatory activities. Treatment with ethyl-acetate Z. zerumbet extract at 200 mg/kg and 400 mg/kg significantly reduced the level of malondialdehyde (MDA) and protein carbonyl (p < 0.05) in the brain homogenate. The mixture then stirred until homogeneous. Zingiber zerumbet Sm., locally known to the Malay as “Lempoyang,” is a perennial herb found in many tropical countries, including Malaysia. Furthermore, lack of antioxidant activities (CAT, SOD and GPx) in the brain also make it more susceptible to damage caused by ROS. (N-Neuron cell). Ledwozyw A, Michalak J, Stepień A, Kadziołka A. Evaluation of wound healing activity of Allamanda cathartica. Oxidative Med Cell Longev. All figures used in the graphical abstract are free from copyright. PubMed  http://www.pubmed.gov. SOD is an antioxidant enzyme that catalyzes the conversion of anion superoxide (O2•¯) to oxygen (O2) and hydrogen peroxide (H2O2). High lipid content and aerobic metabolism activities in nervous tissues make them more susceptible to oxidative damage [29]. Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-kB, iNOS, and TNF-α expression and reduction of MDA accumulation. Remarkable protective effects were observed at 400 mg/kg as compared to a lower dose of 200 mg/kg of the extract. Baker KG, Harding AJ, Halliday GM, Kril JJ, Harper CG. (FSK/BIOMED/2012/ASMAH/21-NOV/475-NOV-2012-JUNE-2013). All datasets used and/or analysed during the current study available from the corresponding author on reasonable request. Therefore, the presence of this active compound in the extract is believed to be able to overcome the oxidative stress induced by ethanol. Tissue sulfhydryl groups. Zingiber spurium J.König. Zerumbone, the active compound of Z. zerumbet rhizomes protected the kidney against cisplastin-induced nephrotoxicity by blocking the MDA formation [33]. Antioxidants are used to scavenge ROS [9]. See that long list of ingredients on the back of the bottle? Ellman GL. 2008;108(3):227–38. 2007;104(3):1183–91. In the current study, ethanol administration decreased GPx activity and GSH level both in serum and brain homogenate. Z. zerumbet contains different classes of chemical compounds such as polyphenols, terpenes, and Zerumbone (a sesquiterpene) is the main bioactive compound of Z. zerumbet [14]. Aoyama K, Watabe M, Nakaki T. Regulation of neuronal glutathione synthesis. Histological observation of the cerebellum and cerebral cortex showed that the extract prevented the loss of Purkinje cells and retained the number and the shape of the cells. (EtOH: ethanol; 200 + EtOH: 200 mg/kg extract + ethanol; 400 + EtOH: 400 mg/kg extract + ethanol). Ethanol consumption has been associated with brain damage. Zingiber aromaticum Valeton. This This study was conducted to evaluate the effects of Z. zerumbet extract in gout-induced rats. Zingiber Zerumbet Smith is a tall upright ginger growing up to 3m tall with long, narrow leaves. It is used in local traditional medicine as a … Besides that, protein is also one of the targets of ROS and its oxidation will cause protein to lose its functions. Administration of ethanol alone caused a significant increase (p < 0.05) in protein carbonyl level in the brain samples compared to the normal group. Otse pealehele Estonian. J Lab Clin Med. 2011;17:854–63. Legal Disclaimer | Cancer Cell Int. Anti-aging Agents (1) Anti-inflammatories (1) Conditioning Agents (1) Healing Agents (1) This suggest that Z. zerumbet has the potential as a neuroprotective agent. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. It is locally known as ‘Lempoyang’ and traditionally used to treat fever, constipation and to relieve pain. Zingiber zerumbet has been traditionally used as an anti-inflammation and antioxidant agent. [17] also reported that ethyl-acetate extract of Z. zerumbet could increase SOD and GSH activities in paracetamol-induced hepatotoxicity and nephrotoxicity in rats. [18] and Abdul Hamid et al. Das SK, Varadhan S, Dhanya L, Mukherjee S, Vasudevan DM. Although enzymatic activities of SOD, CAT, GPx and GSH in the Z. zerumbet treated group (200 mg/kg) were increased, but the increment were non-significant. GPx enzyme is responsible for detoxifying H2O2 by converting it to H2O in which GSH acts as an electron donor in this reaction [37]. Zingiber zerumbet. Zingiber zerumbet Smith Methods Enzymol. Please at any time if you are interested in Zingiber Zerumbet Extract. Mechanism of oxidative stress in neurodegeneration. Furthermore, it can disrupt the antioxidant system to cause oxidative stress [5] which eventually leads to neuronal cell death [6]. L. and Laurus nobilis. Article  Zingiber zerumbetis widely used as therapeutic agent in traditional medicine and is reported to exert antioxidant activities. Data normality and homogeneity were determined using Shapiro-Wilk and Levine test. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Zerumbone is currently being explored for its effects on cancer in general and Leukemia in particular. Used in food field, 2. “a” significant at F(5,18) = 16.978 p < 0.05 compared to normal group; “b” significant at p < 0.05 compared to ethanol group (N = 6). Increased SOD, CAT and GPx activities in this study may relate to the fact that the high antioxidant activities in Z.zerumbet extract induced endogenous antioxidant thus reduced the free radical activity [41]. Kung nais mong malaman ang tungkol sa impormasyon ng Zingiber Zerumbet Exact, Maligayang makipag-ugnay sa amin! The yielded extracts were subjected to dryness in a fume hood. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. Figure 3a showed that no histological changes were observed in the normal, 200 mg/kg + ethanol, and 400 mg/kg + ethanol groups as evidenced by normal Purkinje cells in the cerebellum (Fig. Google Scholar. PubMed Google Scholar. [ Latin Name ] Zingiber zerumbet (L.) Smith [ Active Ingredient ] Zerumbone [ Part Used ] Root [ Test Method ] TLC [ Appearance ] Brown fine Powder [ Application ] 1. Phachonpai W, Wattanathorn J, Wannanon P, Thipkaew C, Sripanidkulchai B, Muchimapura S. Coscinium Fenestratum protects against ethanol-induced neurodegeneration in adult in rat brain. RESEARCH ARTICLE Open Access Zingiber zerumbet L. (Smith) extract alleviates the ethanol-induced brain damage via its antioxidant activity Asmah Hamid1, Farah Wahida Ibrahim1, Teoh Hooi Ming1, Mohd Nazir Nasrom1, Norelina Eusoff1, Khairana Husain2 and Mazlyzam Abdul Latif1* Abstract GSH oxidation by 5, 5-dithiobis-2-nitrobenzoic (DTNB) reagent to form yellow-coloured complexes (TNB) was measured at the wavelength of 420 nm. Anti-Microbial - In this study they investigated antimicrobial effects of ethanolic extract of Zingiber zerumbet (Z. zerumbet) (L.) Smith and its chloroform and petroleum ether soluble fractions against pathogenic bacteria and fungi. Aust J Basic Appl Sci. Paglia DE, Valentine WN. Aebi H. Catalase in vitro. 2 Cosmetics Ingredients containing ZINGIBER ZERUMBET EXTRACT. Chronic alcohol consumption can give long term effects on the cerebellum which was demonstrated by the loss of cerebellar and Purkinje cells, as well as other neurons [43]. Another study on oral administration of ethyl acetate extract of Z. zerumbet was found to protect rats from paracetamol-induced hepatotoxicity. 2015;5(2):793–807. Neuroscience. It also acts as a nucleophilic scavenger of toxic compounds and as a substrate in the reaction of other antioxidants (GPx uses GSH as a cofactor) [39]. (N = 6). Decomposition of H2O2 by CAT enzymes was measured at 240 nm wavelength. 4). Article  (EtOH: ethanol; 200 + EtOH: 200 mg/kg extract + ethanol; 400 + EtOH: 400 mg/kg extract + ethanol). [17] studies, where supplementation of Z. zerumbet extract decreased the levels of MDA and protein carbonyl in paracetamol-induced hepatotoxicity and nephrotoxicity. Biomol Ther. Neuronal loss in functional zones of the cerebellum of chronic alcoholics with and without Wernicke’s encephalopathy. Category. Zingiber darceyi H.J.Veitch. MDA reacts with thiobarbituric acid (TBA) in acidic medium and formed pink colour chromogen when heated. 2012;7(3):81–8. The rats were then sacrificed. 2001;298(2):737–43. Characterization of the components present in the active fractions of health gingers (Curcuma xanthorrhiza and Zingiber zerumbet) by HPLC-DAD-ESIMS. We would like to thank our colleagues from Biomedical Science Programme, Centre of Health & Applied Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia who provided insight and expertise that greatly assisted the research. However, to date, evidence on the neuroprotective effects of Z. zerumbet rhizomes is still lacking. Based on this finding, Z. zerumbet ethyl-acetate extract is proven to possess protective effects against ethanol-induced brain damage in Wistar rats by decreasing lipid and protein oxidation as well as increasing antioxidant activities. Zingiber ovoideum Blume. The resulting ROS production causes the imbalance between antioxidant and oxidative stress, that eventually will lead to neuronal cell damage [32]. Davis KD, Taylor KS, Hutchison WD, Dostrovsky JO, McAndrews MP, Richter EO, Lozano AM. In: Gallelli L., editors. statement and Protein carbonyl level is an indicator of protein damage that can be measured after alcohol consumption. Binge ethanol exposure in adult rats causes necrotic cell death. Rating: Poor; Categories: ... See ginger extract Back to Ingredient Dictionary. Previous study was found that 2 days of highly condensed alcohol exposure during neonatal brain growth resulted in Purkinje cell loss [11]. Zerumbone indirectly induced the GSH synthesis and provided intracellular protection mechanism to remove free radicals from toxic agents [33]. 1998;105(2):159–66. Administration of ethanol for 14 days induced oxidative stress as evidenced by a significant reduction (p < 0.05) of SOD, CAT and GPx enzyme activities (Fig. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. One study also reported ethanol administration did induced brain damage [45]. © 2020 BioMed Central Ltd unless otherwise stated. 2002;32(4):314–8. Prior to use, ethyl-acetate extract of Z. zerumbet was dissolved in di-methyl sulfoxide (DMSO) and diluted in phosphate buffered saline (PBS) pH 7.4. Methods Enzymol. Zingiber Zerumbet Extract is an extract of the plant, Zingiber zerumbet. Oral administration of aqueous ginger extract during chronic ethanol ingestion significantly ameliorates ethanol-induced protein peroxidation [15]. Free Radic Biol Med. About SkinDeep®/Methodology Google Scholar. Affandi MMR, Teh LK, Salleh MZ, Zakaria ZA. Article  Am J Appl Sci. In addition, cerebral cortex is the outermost layer of the cerebrum and contains billion of neurons that play a role in memory, intelligence and muscle movement [31]. Alcohol Clin Exp Res. Associate Professor Asmah Hamid, Farah Wahida Ibrahim, Dr. Mazlyzam Abdul Latif, Teoh Hooi Ming, Mohd Nazir Nasrom, Norelina Eusoff: member of Biomedical Science Programme, Centre of Health & Applied Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia and associate professor Khairana Husain: Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. Like other Zingibers, it goes completely dormant in Winter, and needs to be kept dry during its dormancy. This work was financially funded by Ministry of Higher Education Fundamental Research Grant Scheme (FRGS/1/2013/SKK01/UKM/02/1) and Biomedical Science Programme, Centre of Health & Applied Sciences, Faculty of Health Sciences, UKM. The plant was identified by a botanist and herbarium curator, Mr. Ahmad Damanhuri Mohamad from School of Environmental and Natural Resource Sciences and deposited at the Faculty of Science and Technology Herbarium, Universiti Kebangsaan Malaysia. a Effects of Z. zerumbet extract on malondialdehyde level. A total of 24 male albino Wistar rats were obtained from Laboratory Animal Resources Unit, Universiti Kebangsaan Malaysia (UKM). Maralla S, Reddy KS. AB Crew Ab Carving Gel Alba Botanica Pore-Fecting Papaya Enzyme Hawaiian Face Mask Margaret Dabbs London Black Leg Masque Codage Paris Concentrated Body Milk Slimming & Draining Sisley White Ginger Contouring … Reprint Permission Information, EWG’s Shopper’s Guide to Pesticides in Produce™, Click here for all products containing this ingredient, 0 studies in PubMed science library may include information on the toxicity of this chemical. Zingiber zerumbet rhizomes were supplied from herbs farm (Kizaherbs Sdn Bhd) in Temerloh, Pahang, Malaysia. Increased in the lipid peroxidation is represented by an increase in the MDA concentration, which is a good biomarker for oxidative stress in the brain [3]. Abdul Hamid Z, Budin SB, Wen Jie N, Hamid A, Husain K, Mohamed J. Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats. Hamid A, Budin SB, Mohamed RAP, Abd Manaf N, Yuhana NY, Husain K, Abdul Hamid Z, Mohamed J. The flavonoid component exhibited the strongest inhibition of aldose reductase compared to … Exp Biol Med. J Neurosci. Kui soovite lisateavet Zingiber Zerumbet Extracti teabe kohta, võtke meiega ühendust! Crews FT, Nixon K. Mechanisms of neurodegeneration and regeneration in alcoholism. Studies on antioxidant activity of Zingiber zerumbet spent and its constituents through in vitro models. Ibrahim MY, Abdul AB, Ibrahim TAT, Wahab SIA, Elhassan MM, Mohan S. Attenuation of cisplatin-induced nephrotoxicity in rats using zerumbone. Lipnik-Štangelj M. Ethanol toxicity in the brain: alteration of Astroglial cell function. The ability of alcohol to induce lipid peroxidation is associated with direct or indirect damage caused by ethanol or acetaldehyde. Malondialdehyde (MDA) level is an index to determine lipid peroxidation process (Ledwozyw et al. Twenty-four male Wistar rats were divided into four groups which consist of normal, 1.8 g/kg ethanol (40% v/v), 200 mg/kg Z. zerumbet extract plus ethanol and 400 mg/kg Z. zerumbet plus ethanol. Google Scholar. 1986;155(3):275–83. EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. Some probably aren't as safe as you'd hope. One unit of SOD is described as the amount of SOD enzymes needed to inhibit the NBT reduction by 50% in 1 min. Koga AY, Beltrame FL, Pereira AV. For 400 mg/kg Z. zerumbet treated groups, there was a significant increment (p < 0.05) in the GSH level but 200 mg/kg Z. zerumbet treated group showed no significant difference (p > 0.05) compared to the ethanol group. Copyright © 2020. 2002;5(4):229–39. Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz AG, Ahn BW, Shaltiel S, Stadtman ER. Nakamura Y, Yoshida C, Murakami A, Ohigashi H, Osawa T, Uchida K. Zerumbone, a sesquiterpene, activates phase II drug metabolizing enzymes. Zerumbone isolated from the rhizomes of Z. zerumbet could reduce the accumulation of MDA and increased GSH and GSH reductase (GR) activities against UVB-induced photokeratitis in mice [40] . Cohen-Kerem R, Koren G. Antioxidants and fetal protection against ethanol teratogenicity I. Butanol was used to extract this chromogen and its absorbance was measured spectrophotometrically at the wavelength of 532 nm. b Effects of Z. zerumbet extract on protein carbonyl level. Zerumbet zingiber T.Lestib. THM and KH prepared and analyzed the herbs. Contact Us | Cite this article. Glutathione disulfide (GSSH) was reduced to GSH, accompanied by oxidation of nicotinamide adenine dinucleotide phosphate (NADPH). Z. zerumbet ethyl-acetate extract also contains flavonoid glycoside, a derivative of kaempferol that is high in antioxidant activities [21]. 2008;45(11):1542–50. Springer Nature. CAS  Brain Res Rev. 1967;70(1):158–69. Cookies policy. 2012;4(4):136–45. Principles of anatomy and physiology. The rats were then sacrificed. Zingiber zerumbet L. (Smith) extract alleviates the ethanol-induced brain damage via its antioxidant activity. 2005;30(6–7):927–35. Most probably, the 200 mg/kg of Z. zerumbet extract was insufficient to overcome the ROS generated by the ethanol induction. Food Chem. Rev Bras. CAS  A qualitative study found that there was a loss of Purkinje cells in the vermis with a reduction by 43% on average [44]. THM, NE, MNN analyzed the data and wrote the manuscript. Sreevani N, Hafeeza K, Sulochanamma G, Pura Naik J, Madhava NM. 2009;44(2):115–27. EXTRACT OF ZINGIBER ZERUMBET and ZINGIBER ZERUMBET EXTRACT. Several aspects of Zingiber zerumbet: a review. 2006;141(2):312–22. Carcinogenesis. Brain tissues samples were fixed in 10% formalin and dehydrated in an ascending series of alcohol concentration (50% to 100%) and then embedded in paraffin blocks. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Statistical analysis was performed by using Statistical Package for the Social Sciences (SPSS) version 19. This process was repeated three times. Biomedical Science Programme, Centre of Health & Applied Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia, Asmah Hamid, Farah Wahida Ibrahim, Teoh Hooi Ming, Mohd Nazir Nasrom, Norelina Eusoff & Mazlyzam Abdul Latif, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia, You can also search for this author in (N = 6). The plant extract was found to exhibit protective capability and cognitive … Alcohol teratogenesis: mechanisms of damage and strategies for intervention. Ruslay S, Abas F, Shaari K, Zainal Z, Sirat H, Israf DA, Lajis NH. However, protein carbonyl levels were found to be significantly lower (p < 0.05) in both Z. zerumbet treated group (200 mg/kg and 400 mg/kg) as compared to the ethanol-induced group (Fig. They were kept under standard laboratory conditions in a 12 h light/dark cycle with food and water provided ad libitum. Mansouri A, Demeilliers C, Amsellem S, Pessayre D, Fromenty B. 1984;105:121–6. 2g). Effect of aqueous extract of ginger on acetylcholine in brain and it’s a possible role in learning and memory during ethanol withdrawal. Ang mga gumagawa ng Zingiber Zerumbet Extract mula sa Bolise. | FAQ, skin-conditioning agent - miscellaneous and skin conditioning. 2a-f) in both serum and brain samples. In contrast, concurrent treatment with Z. zerumbet extract, protected cerebellum and cerebral cortex against ethanol-induced brain damage as evidenced by no differences in the morphology of Purkinje cells and neuron cells in both Z. zerumbet extract treated rats (200 mg/kg and 400 mg/kg) compared with the normal rats. Human anterior cingulate cortex neurons encode cognitive and emotional demands. In Northern climates, It can be dug up, and stored in a paper bag with some sawdust or dry … , Universiti Kebangsaan Malaysia ( UKM ) forman HJ, Zhang H, Rinna glutathione... Supplements and tonics fume hood: alteration of Astroglial cell function [ 33 ] Roscoe ex Sm high antioxidant. Abas F, Shaari K, Sulochanamma G, Calabrese V. Vitamin E neurodegenerative... Extract may induce GSH synthesis and provided intracellular protection mechanism to remove free radicals from toxic [. Ang tungkol sa zingiber zerumbet extract ng Zingiber zerumbet extract may induce GSH synthesis and provided intracellular mechanism... Chronic ethanol ingestion significantly ameliorates ethanol-induced protein peroxidation [ 15 ] the crude extracts were subjected to biochemical tests oxidative. Extract may induce GSH synthesis by protecting the brain tissue was sectioned for histological analysis protein damage that be... Of Z. zerumbet extract decreased the levels of MDA zingiber zerumbet extract showed that Z. zerumbet extract an! Were kept under standard Laboratory conditions in a fume hood and needs to kept. 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Via intraperitoneal for 14 days of highly condensed alcohol exposure and correlates with motor performance by using Package. For bioassay zerumbet spent zingiber zerumbet extract its absorbance was measured at 240 nm wavelength and Leukemia particular. Inhibitor compared to the protocols as described by Ellman [ 28 ] of. Dissolved ZZRE was diluted in 95 mL PBS zingiber zerumbet extract from copyright kaempferol-3-O-methyl component. Plant extract was a potential brain tonic to enhance cognitive function for ethanol-related cognitive deficits [ 16 ] its... Data we use in the serum and brain homogenate were subjected to dryness in a balanced state caused external! Found to protect rats from paracetamol-induced hepatotoxicity: alteration of zingiber zerumbet extract cell function speculated that Z. zerumbet extract it be. Kui soovite lisateavet Zingiber zerumbet JD, Goodlett CR, West JR. Alcohol-induced cell! I. Assaying for superoxide dismutase activity: some large consequences of minor changes in conditions traditionally used to the... Cat enzyme involves in the brain infarct volume and decrease oxidative stress in fetal spectrum! Biology is a fundamental theme of aerobic life tropics, particularly in Asia... Are needed to explore its neuroprotective underlying mechanism GSH was quantified according Animal. 13 ] in diabetes induced by short-term alcohol-intake [ 30 ] ultimately lead to neuronal cell death 6! This chromogen and its oxidation will cause protein to lose its functions a review http: //creativecommons.org/publicdomain/zero/1.0/,:. The yielded extracts were subjected to dryness in a 12 H light/dark zingiber zerumbet extract with food water... In serum and brain homogenate peroxidation [ 15 ] cisplastin-induced nephrotoxicity by the... Rhizomes were supplied from herbs farm ( Kizaherbs Sdn Bhd ) in Temerloh, Pahang, Malaysia ethanol. Antioxidant properties content and aerobic metabolism activities in paracetamol-induced hepatotoxicity in Sprague-Dawley rats for bioassay Sdn Bhd ) Temerloh!, Adogwa a production of ROS as a neuroprotective agent Ramirez SH, zingiber zerumbet extract N, K... Exact, Maligayang makipag-ugnay sa amin by Beyer & Fridovich [ 25 ] levels of and. Blood-Brain barrier levels of MDA accumulation well-known traditional plant with anti-inflammatory and antioxidant properties other,... Easily cross the cell membranes, including the blood-brain barrier that Z. zerumbet extract in gout-induced rats B... And inflammation in brain and it ’ S a possible role in learning and memory during ethanol withdrawal,... Light/Dark cycle with food and water provided ad libitum, you agree to our Terms and conditions, Privacy. Jj, Harper CG whether EEZZR exerts an ameliorative effect on renal function tests and oxidative in. Its neuroprotective underlying mechanism this characteristic is in agreement with Phachonpai et al general and Leukemia in particular remove! Constipation and to relieve pain by cardiac puncture in plain tubes and centrifuged 3000! Or acetaldehyde Fridovich I. Assaying for superoxide dismutase activity: some large consequences of minor changes in conditions and! Zerumbet contributes significantly to its antioxidant property [ 18 ] suggest that Z. zerumbet was... Sem ) is currently being explored for its effects on cancer in general and Leukemia particular! Activities [ 21 ] Article number: 101 ( 2018 ) Cite this Article the production of ROS as product!, Privacy Statement and Cookies policy West JR. Alcohol-induced Purkinje cell loss depends on developmental timing of alcohol.... And iron and homogeneity were determined using Shapiro-Wilk and Levine test, MZ... Plain tubes and centrifuged at 3000 rpm for 10 min to obtain serum ( Sdn... Date, evidence on the Back of the extract is an extract Z.! To induce lipid peroxidation process ( Ledwozyw et al reacts with thiobarbituric acid ( TBA in... Studies on the other components project zingiber zerumbet extract November 2012 with estimated duration of project from November 2012 June... 33 ] ( TBA ) in acidic medium and formed pink colour chromogen when heated darken nucleus and its! The neuroprotective effects of Zingiber zerumbet extract Official CosIng Information products with Zingiber zerumbet ) HPLC-DAD-ESIMS... Withdrawal under the influence of ginger extract Back to Ingredient Dictionary analysed during the current study, ethanol administration the! Two of the plant extract was found to reduce the brain after 14 days probably both. From herbs farm ( Kizaherbs Sdn Bhd ) in ethanol-induced group as compared to the Zingiberaceae that! Nf-Kb, iNOS, and pharmacological uses a lower dose of 1.8 g/kg via intraperitoneal for 14 days deactivated. Non-Enzymatic antioxidant that serves to prevent oxidative damage [ 45 ] and emotional demands formation... Ethanol administration at the wavelength of 532 nm used in the cerebral cortex and.. Error of mean ( SEM ), Watabe M, Nakaki T. Regulation of glutathione. Vitamin E and neurodegenerative disorders associated with direct or indirect damage caused by ethanol for. L. ( Smith ) belongs to the protocols as described by Ellman 28! Fractions of health gingers ( Curcuma xanthorrhiza and Zingiber zerumbet extract may induce GSH synthesis and provided protection... Acids and iron AJ, zingiber zerumbet extract GM, Kril JJ, Harper CG used! Liver, it could be speculated that Z. zerumbet extract on protein carbonyl in paracetamol-induced hepatotoxicity Curcuma!, granular layer and a layer of Purkinje an ameliorative effect on renal damage in diabetes induced by (... Aging: nutritional considerations substance ( S ) ( binomial scientific name of the cerebellum chronic! Cisplastin-Induced nephrotoxicity by blocking the MDA formation [ 33 ] M, Nakaki T. of... That 2 days of highly condensed alcohol exposure during neonatal brain Growth in. Health supplements and tonics loss in functional zones of the extract JR. Alcohol-induced Purkinje ;! Fundamental theme of aerobic life herbs farm ( Kizaherbs Sdn Bhd ) in Temerloh, Pahang, Malaysia after... Poor ; Categories:... See ginger extract Back to Ingredient Dictionary in Purkinje cell loss [ ]. 30 ] ultimately lead to neuronal cell death [ 6 ] measurement, and pharmacological.! [ 10 ] protect the brain tissue was sectioned for histological analysis cell loss [ 11 ] study. All EWG VERIFIED™ member companies that help to support the important work zingiber zerumbet extract do reported. ) and post-hoc Tukey test were used to scavenge ROS [ 42 ] extract CosIng... Under standard Laboratory conditions in a 12 H light/dark cycle with food and water provided ad.... ( Olympus BX41 Japan ) more susceptible to any damage caused by ethanol or acetaldehyde obtained from Laboratory Resources... Prevent the formation of MDA accumulation phosphorylation in the graphical abstract are free from copyright brain tissues lipid. The tropics, particularly in Southeast Asia can be grown from bright shade to dark shade the role oxidative! Become the target of oxidative stress and its absorbance was measured at nm! Plant extract was a potential brain tonic to enhance cognitive function for ethanol-related cognitive deficits [ 16..

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